Human defensin-inspired discovery of peptidomimetic antibiotics.
Gan LuoJue ZhangHanBin WangYaQi SunBaoLi ChengZhiPeng XuYan ZhangHui LiWuYuan LuElizabeta NemethTomas GanzXiang-Ming FangPublished in: Proceedings of the National Academy of Sciences of the United States of America (2022)
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.