Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.
Daniel P HurkmansElizabeth M E VerdegaalSabrina A HoganRik de WijnLies HovestadDianne M A van den HeuvelRob RuijtenbeekMarij J P WeltersMandy van BrakelEdwin A BasakHerbert M PinedoCor H J LamersHarmen J G van de WerkenJohn P GrotenReno DebetsMitchell Paul LevesqueReinhard DummerEllen KapiteijnRon H J MathijssenJoachim G J V AertsSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2021)
Blood-based kinase activity profiling for response prediction to immune checkpoint inhibitors in melanoma and NSCLC revealed increased kinase activity in pathways associated with T-cell function and led to a classification model with a highly accurate classification rate in cross-validation groups. The predictive value of kinase activity profiling is prospectively verified in an ongoing trial.