Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.
Germain HonvoOlivier BruyèreAnton GeerinckNicola VeroneseJean-Yves ReginsterPublished in: Advances in therapy (2019)
This new meta-analysis suggests that CS provides a moderate benefit for pain and has a large effect on function in knee OA, however with large inconsistency. The risks of bias, brand and study size were the factors explaining heterogeneity among the clinical trial results.
Keyphrases
- knee osteoarthritis
- systematic review
- double blind
- placebo controlled
- clinical trial
- phase ii
- meta analyses
- phase iii
- open label
- study protocol
- chronic pain
- case control
- total knee arthroplasty
- neuropathic pain
- single cell
- human health
- randomized controlled trial
- high intensity
- phase ii study
- spinal cord
- radiation therapy