Site-specific 68 Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models.

Jonatan DewulfTal FlieswasserTim DelahayeChristel VangestelAlan MirandaHans de HaardJulie JacobsEvelien SmitsTim Van den WyngaertFilipe Elvas

Published in: EJNMMI radiopharmacy and chemistry (2023)

Ga]Ga-NOTA-anti-CD70 VHH showed excellent in vivo targeting of CD70 in human cancer xenografts. PET imaging using this radioimmunoconjugate holds promise as a non-invasive method to identify and longitudinally follow-up patients who will benefit most from anti-CD70 therapies.

Keyphrases

pet imaging
pet ct
positron emission tomography
nk cells
computed tomography
big data
squamous cell carcinoma
cancer therapy
deep learning
bone marrow
lymph node metastasis
pluripotent stem cells