Neurovascular cells when cultured in combination with skeletal myocytes promoted myocyte fusion with concomitant increase in expression of various neuromuscular genes. This triculture system may be used to gain a deeper understanding of the effects of the neurovascular niche on skeletal muscle biology and pathophysiology.
Keyphrases
- endothelial cells
- skeletal muscle
- induced apoptosis
- high glucose
- poor prognosis
- induced pluripotent stem cells
- cell cycle arrest
- vascular endothelial growth factor
- insulin resistance
- genome wide
- spinal cord
- oxidative stress
- binding protein
- gene expression
- long non coding rna
- dna methylation
- type diabetes
- cell proliferation
- metabolic syndrome
- spinal cord injury
- adipose tissue
- transcription factor