Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance.
Laura FormentiniAlexander J RyanManuel Gálvez-SantistebanLeslie CarterPam TaubJohn D LapekDavid J GonzalezFrancisco VillarrealTheodore P CiaraldiJosé M CuezvaRobert R HenryPublished in: Diabetologia (2017)
Overall, our data highlight IF1 as a novel regulator of lipid metabolism and metabolic disorders, and a possible target for therapeutic intervention.
Keyphrases
- insulin resistance
- skeletal muscle
- endothelial cells
- adipose tissue
- randomized controlled trial
- high fat diet
- oxidative stress
- metabolic syndrome
- polycystic ovary syndrome
- type diabetes
- induced pluripotent stem cells
- electronic health record
- high fat diet induced
- transcription factor
- big data
- machine learning
- glycemic control
- data analysis