A Lipid Signature with Perturbed Triacylglycerol Co-Regulation, Identified from Targeted Lipidomics, Predicts Risk for Type 2 Diabetes and Mediates the Risk from Adiposity in Two Prospective Cohorts of Chinese Adults.
Gaokun QiuHao WangQi YanHongXia MaRundong NiuYanshou LeiYang XiaoLue ZhouHandong YangChengwei XuXiaomin ZhangMeian HeHuiru TangZhibin HuAn PanHongbing ShenTangchun WuPublished in: Clinical chemistry (2022)
Our findings suggested notable perturbed co-regulation, inferred from differential correlation networks, between oleyl chain- and palmitoyl chain-containing TAGs before diabetes onset, with the oleyl chain-containing TAG 50:3 at the center, and provided novel etiological insight regarding lipid dysregulation in the progression from adiposity to overt T2D.