The Causal Role of Mitochondrial Dynamics in Regulating Insulin Resistance in Diabetes: Link through Mitochondrial Reactive Oxygen Species.

Hung-Yu LinShao-Wen WengYen-Hsiang ChangYu-Jih SuChih-Min ChangChia-Jen TsaiFeng-Chih ShenJiin-Haur ChuangTsu-Kung LinChia-Wei LiouChing-Yi LinPei-Wen Wang

Published in: Oxidative medicine and cellular longevity (2018)

Our results discovered the causal role of mtDYN proteins in regulating IR resulted from diabetes-susceptible mitochondrial haplogroup. The existence of a bidirectional interaction between mtDYN and mtROS plays an important role. Direct intervention to reverse profission in mtDYN provides a novel therapeutic strategy for IR and T2D.

Keyphrases

oxidative stress
type diabetes
reactive oxygen species
cardiovascular disease
glycemic control
randomized controlled trial
mitochondrial dna
dna methylation
skeletal muscle
weight loss