Mesenchymal stem cells and platelet rich plasma therapy for knee osteoarthritis: an umbrella review of systematic reviews with meta-analysis.
Feng LinXinguang ZhangCunbao CuiPublished in: Annals of Saudi medicine (2024)
The effect of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) therapy on knee osteoarthritis (KOA) has been contradictory in previous meta-analyses. This umbrella review on published meta-analyses aimed to investigate the effect of MSCs and PRP on KOA. We systematically searched Scopus, PubMed, and Cochrane databases to include related meta-analyses. The outcome included studies reporting visual analog scale scores, the Western Ontario and McMaster Universities Osteoarthritis Index, Whole-Organ Magnetic Resonance Imaging Scores, International Knee Documentation Committee scores, and the Knee injury and Osteoarthritis Outcome Score. A total of 28 meta-analyses with 32 763 participants. MSCs and PRP therapies were significantly associated with an improvement in KOA scores. This umbrella meta-analysis supports the beneficial health effects of MSCs and PRP in KOA.
Keyphrases
- meta analyses
- knee osteoarthritis
- platelet rich plasma
- mesenchymal stem cells
- umbilical cord
- systematic review
- randomized controlled trial
- magnetic resonance imaging
- bone marrow
- cell therapy
- public health
- healthcare
- computed tomography
- mental health
- stem cells
- rheumatoid arthritis
- electronic health record
- health information
- replacement therapy
- drug induced