Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727).

Holly Tovey Orsolya Sipos Joel S Parker Katherine A Hoadley Jelmar Quist Sarah Kernaghan Lucy Suzanne Kilburn Roberto Salgado Sherene Loi Richard D Kennedy Ioannis Roxanis Patrycja Gazinska Sarah E Pinder Judith M Bliss Charles M Perou Syed Haider Anita Grigoriadis Andrew N J Tutt Maggie Chon U Cheang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

High immune features predict docetaxel response, and high DDR signature scores predict carboplatin response in treatment-naïve mTNBC. Integrating multimodal DDR and immune-related markers identifies subgroups with differential treatment sensitivity. Treatment options for patients with immune-low and DDR-proficient tumors remains an outstanding need. Caution is needed using PT-derived transcriptional signatures to direct treatment in mTNBC, particularly DDR-related markers following prior chemotherapy.

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