c-Jun Overexpression Accelerates Wound Healing in Diabetic Rats by Human Umbilical Cord-Derived Mesenchymal Stem Cells.

Chun Yue Zi Guo Kelly Long Yufang Luo Jingjing Yuan Xin-Xing Wan Zhaohui Mo

Published in: Stem cells international (2020)

c-Jun overexpression promoted hUC-MSC proliferation and migration in vitro and accelerated diabetic wound closure, reepithelization, and angiogenesis by hUC-MSCs in vivo. These beneficial effects of c-Jun overexpression in diabetic wound healing by hUC-MSCs were at least partially mediated by increased PDGFA and HGF levels in wound tissues.

Keyphrases

wound healing
umbilical cord
mesenchymal stem cells
diabetic rats
cell proliferation
endothelial cells
transcription factor
oxidative stress
gene expression
induced pluripotent stem cells
pluripotent stem cells
type diabetes