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LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression.

Jin-Hai TianXu CaoZongying JiangJia WangWan FanShaoting ZhangSien ZhaoJianmin Sun
Published in: Cancer medicine (2024)
CCAT2 plays a crucial role in CRC progression by modulating the ERK and Wnt signaling pathways through its interaction with GNB2. These findings highlight the importance of CCAT2 as a key regulatory element in the mechanisms underlying CRC proliferation and metastasis.
Keyphrases
  • signaling pathway
  • pi k akt
  • cell proliferation
  • induced apoptosis
  • epithelial mesenchymal transition
  • stem cells
  • poor prognosis
  • long non coding rna
  • transcription factor
  • oxidative stress