Genetic determinants of daytime napping and effects on cardiometabolic health.
Hassan S DashtiIyas DaghlasJacqueline M LaneYunru HuangMiriam S UdlerHeming WangHanna M OllilaSamuel E JonesJaegil KimAndrew R Woodnull nullMichael N WeedonStella AslibekyanMarta GarauletRicha SaxenaPublished in: Nature communications (2021)
Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.
Keyphrases
- genome wide
- sleep quality
- genome wide association study
- obstructive sleep apnea
- copy number
- dna methylation
- physical activity
- public health
- body mass index
- blood pressure
- depressive symptoms
- healthcare
- mental health
- metabolic syndrome
- insulin resistance
- type diabetes
- gene expression
- weight loss
- risk assessment
- human health
- body weight
- cross sectional
- weight gain
- intellectual disability
- skeletal muscle
- genome wide association
- emergency department
- climate change
- adverse drug
- high fat diet induced