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A phase 2B randomised trial of hyperbaric oxygen therapy for ulcerative colitis patients hospitalised for moderate to severe flares.

Parambir S DulaiLaura E RaffalsDavid HudesmanMichael ChioreanRaymond CrossTasneem AhmedMichael WinterShannon ChangDavid FudmanCharlotte SadlerErnest L ChiuFrank L RossGary ToupsM Hassan MuradKinjal SethuramanJames R HolmRenie GuilliodBenjamin LevineJay C BuckeyCorey A Siegel
Published in: Alimentary pharmacology & therapeutics (2020)
Hyperbaric oxygen appears to be effective for optimising response to intravenous steroids in UC patients hospitalised for acute flares, with low rates of re-hospitalisation or colectomy at 3 months. An optimal clinical response is achieved with 5 days of hyperbaric oxygen. Larger phase 3 trials are needed to confirm efficacy and obtain labelled approval.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • prognostic factors
  • ulcerative colitis
  • clinical trial
  • randomized controlled trial
  • liver failure
  • early onset
  • study protocol
  • high intensity