RNF135 Promotes Human Osteosarcoma Cell Growth and Inhibits Apoptosis by Upregulating the PI3K/AKT Pathway.

Bingyao ChenYinglong ZhangGuangze SongXing Wei

Published in: Cancer reports (Hoboken, N.J.) (2024)

These results supported that RNF135 contributes to human OS development through PI3K/AKT-dependent mechanisms. Targeting RNF135 may provide a new therapeutic approach for treating this human malignancy.

Keyphrases

endothelial cells
pi k akt
induced pluripotent stem cells
cell cycle arrest
signaling pathway
pluripotent stem cells
cell proliferation
oxidative stress
cell death
dna damage response
endoplasmic reticulum stress
dna repair