Gestation and breastfeeding in schistosomotic mice differentially alters the expression of histone deacetylases (HDACs) in adult offspring.

Gabriela Calixto Ribeiro de HolandaFabrício Oliveira SoutoMaria da Conceição SilvaVirgínia Maria Barros de LorenaVlaudia Maria Assis CostaMonica Camelo Pessôa de Azevedo AlbuquerqueValdênia Maria Oliveira de SouzaJosé Luiz de Lima Filho

Published in: Memorias do Instituto Oswaldo Cruz (2020)

Breastfeeding induced the expression of HDACs from various classes involved in reducing inflammatory responses. However, gestation enhanced the expression of a single HDAC and breastfeeding or gestation appears to favour multiple IL-10-dependent pathways, but not cells with a regulatory phenotype.

Keyphrases

preterm infants
poor prognosis
binding protein
induced apoptosis
gestational age
long non coding rna
high fat diet
transcription factor
metabolic syndrome
dna methylation
adipose tissue
insulin resistance
endoplasmic reticulum stress
signaling pathway
high fat diet induced
oxidative stress
preterm birth