Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals.

Chiara Saponaro Silvia Sabatini Melania Gaggini Fabrizia Carli Chiara Rosso Vincenzo Positano Angelo Armandi Gian Paolo Caviglia Riccardo Faletti Elisabetta Bugianesi Francesco Rubino

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

These findings propose VF as an early indicator of NAFLD progression independently of BMI, which may allow for evidence-based prevention and intervention strategies.

Keyphrases

insulin resistance
adipose tissue
high fat diet
randomized controlled trial
body mass index
polycystic ovary syndrome
oxidative stress
high fat diet induced
bone mineral density
weight gain
metabolic syndrome
type diabetes
skeletal muscle
glycemic control
physical activity