The IRE1α-endonuclease plays a dual role in regulating the XBP1/miRNA-34a axis and PD-1 expression within Natural Killer cells in Hodgkin Lymphoma.

Karolina BednarskaGayathri ThillaiyampalamSally MujajJamie NourseJay GunawardanaMuhammed B SabdiaSoi C LawAnna PilaarQingyan CuiLilia M de LongFrank VariMaher K GandhiAlexandre S Cristino

Published in: Acta haematologica (2024)

The IRE1α-endonuclease emerges as a key player, simultaneously regulating the XBP1s/microRNA-34a-5p/PD-1 axis in NK-cells, a process disrupted in HL. Targeting the IRE1α-pathway holds promise as a therapeutic strategy to optimise NK-cell functions in Hodgkin Lymphoma treatments.

Keyphrases

hodgkin lymphoma
nk cells
endoplasmic reticulum stress
natural killer cells
dna repair
poor prognosis
cancer therapy
big data
binding protein
drug delivery
oxidative stress
deep learning