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Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.

Rebecca N JeromeMeghan Morrison JolyNan KennedyJana K Shirey-RiceDan M RodenGordon R BernardKenneth J HolroydJoshua C DennyJill M Pulley
Published in: Drug safety (2021)
By connecting and integrating in vivo and in silico data, SA-PheWAS offers an opportunity to supplement current methods for predicting or confirming safety signals associated with therapeutic agents.
Keyphrases
  • endothelial cells
  • electronic health record
  • molecular docking
  • induced pluripotent stem cells
  • emergency department
  • pluripotent stem cells
  • artificial intelligence
  • molecular dynamics simulations
  • drug induced