Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar.

T ShaoW TangY LiD GaoK LvP HeY SongS GaoM LiuYihua Chen Zheng-Fang Yi

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2019)

WG449E is a potential candidate for the treatment of hypertrophic scars.WG449E downregulates the mRNA and protein levels of collagen in hypertrophic scar-derived fibroblasts through inhibiting Smad2/3 phosphorylation and nucleic localization. WG449E blocks HSF migration and invasion by regulating F-actin assignment. In addition, WG449E induces HSF apoptosis through the activation of cleaved-caspase3.

Keyphrases

small molecule
cell death
heat shock
wound healing
protein protein
oxidative stress
endoplasmic reticulum stress
epithelial mesenchymal transition
signaling pathway
binding protein
transforming growth factor
cell proliferation
human health
smoking cessation
heat shock protein
heat stress