Yihua Chen (Y Chen)

ResearcherID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 31

Top Venues

Journal of medicinal chemistry

Nature communications

Future medicinal chemistry

ACS central science

University of Illinois at Chicago

Shanghai Institute of Materia Medica Chinese Academy of Sciences (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Illinois at Chicago Aug 01 2006 - Aug 01 2009

United States

Postdoctoral Research Associate :: College of Pharmacy

Education History

Shanghai Institute of Materia Medica Chinese Academy of Sciences Sep 01 2001 - Jul 15 2006

China

PHD

Publications

Huang Chen, Aiwu Bian, Wenbo Zhou, Ying Miao, Jiangnan Ye, Jiahui Li, Peng He, Qiansen Zhang, Yue Sun, Zhenliang Sun, Chaowen Ti, Yihua Chen, Zheng-Fang Yi, Mingyao Liu
Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment. ACS central science 10 (3) (2024)
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-Kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature communications 15 (1) (2024)
Weikai Guo, Zhengfan Yang, Kexiao Wang, Wenyu Li, Yanyang Zhao, Yuqing Yang, Wenjing Chang, Zhen Gong, Zhou Liu, Yihua Chen, Qiming Li
Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of medicinal chemistry 67 (3) (2024)
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-Kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature communications 15 (1) (2024)
Weikai Guo, Zhengfan Yang, Kexiao Wang, Wenyu Li, Yanyang Zhao, Yuqing Yang, Wenjing Chang, Zhen Gong, Zhou Liu, Yihua Chen, Qiming Li
Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of medicinal chemistry 67 (3) (2024)
Weikai Guo, Zhengfan Yang, Kexiao Wang, Wenyu Li, Yanyang Zhao, Yuqing Yang, Wenjing Chang, Zhen Gong, Zhou Liu, Yihua Chen, Qiming Li
Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of medicinal chemistry (2024)
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-Kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature communications 15 (1) (2024)
Huang Chen, Aiwu Bian, Wenbo Zhou, Ying Miao, Jiangnan Ye, Jiahui Li, Peng He, Qiansen Zhang, Yue Sun, Zhenliang Sun, Chaowen Ti, Yihua Chen, Zheng-Fang Yi, Mingyao Liu
Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment. ACS central science 10 (3) (2024)
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-Kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature communications 15 (1) (2024)
Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-Kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nature communications 15 (1) (2024)
Jia He, Luzhen Wang, Dazhao Mi, Tian Guan, Wenjing Liu, Peng He, Haijun Gu, Yuzhan Li, Yangrui Peng, Ai-Qun Jia, Ceshi Chen, Yihua Chen
Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer. Journal of medicinal chemistry (2023)
Haijun Gu, Ting Zhang, Tian Guan, Min Wu, Shen Li, Yunqi Li, Mengmeng Guo, Lin Zhang, Yangrui Peng, Dazhao Mi, Mingyao Liu, Zheng-Fang Yi, Yihua Chen
Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer. Journal of medicinal chemistry (2023)
Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen
Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance. Journal of medicinal chemistry (2023)
Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen
Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance. Journal of medicinal chemistry 66 (9) (2023)
Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen
Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance. Journal of medicinal chemistry 66 (9) (2023)
Wangrui Jin, Tao Zhang, Wenbo Zhou, Peng He, Yue Sun, Shijia Hu, Huang Chen, Xinglong Ma, Yangrui Peng, Zheng-Fang Yi, Mingyao Liu, Yihua Chen
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. Journal of medicinal chemistry 65 (9) (2022)
Haijun Gu, Jia He, Yuzhan Li, Dazhao Mi, Tian Guan, Weikai Guo, Bo Liu, Yihua Chen
B-cell Lymphoma 6 Inhibitors: Current Advances and Prospects of Drug Development for Diffuse Large B-cell Lymphomas. Journal of medicinal chemistry 65 (23) (2022)
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Huang Chen, Jiangnan Ye, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zheng-Fang Yi, Yihua Chen
Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr 705 /Ser 727 Inhibitory Activity for Gastric Cancer Treatment. Journal of medicinal chemistry 65 (19) (2022)
Peng He, Aiwu Bian, Ying Miao, Wangrui Jin, Huang Chen, Jia He, Liting Li, Yue Sun, Jiangnan Ye, Mingyao Liu, Zheng-Fang Yi, Wenbo Zhou, Yihua Chen
Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment. Journal of medicinal chemistry 65 (22) (2022)
Huang Chen, Wenbo Zhou, Aiwu Bian, Qiansen Zhang, Ying Miao, Shifen Xu, Jiangnan Ye, Shi-Fen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen, Mingyao Liu, Zheng-Fang Yi
Selectively targeting STAT3 using a small molecule inhibitor is a potential therapeutic strategy for pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Haixiang Pei, Weikai Guo, Yangrui Peng, Hai Xiong, Yihua Chen
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective. Medicinal research reviews 42 (4) (2022)
Haijun Gu, Ting Zhang, Yunqi Li, Yuan He, Tian Guan, Weiqiong Kan, Peng He, Zhengfang Yi, Yihua Chen
Discovery of 1,5-diaryl-1,2,4-triazole derivatives as myoferlin inhibitors and their antitumor effects in pancreatic cancer. Future medicinal chemistry 14 (20) (2022)
Weikai Guo, Yajing Xing, Qiansen Zhang, Jiuqing Xie, Dongxia Huang, Haijun Gu, Peng He, Miaoran Zhou, Shi-Fen Xu, Xiufeng Pang, Mingyao Liu, Zheng-Fang Yi, Yihua Chen
Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth. Journal of medicinal chemistry 63 (2) (2020)
Feifei Yang, Lina Han, Na Zhao, Yang Yang, Di Ge, Hua Zhang, Yihua Chen
Synthesis and biological evaluation of thiophene-based hydroxamate derivatives as HDACis with antitumor activities. Future medicinal chemistry 12 (8) (2020)
Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi, Mingyao Liu, Yihua Chen
Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 (9) (2020)
Liang Li, Dazhao Mi, Haixiang Pei, Qiuhui Duan, Xinyue Wang, Wenbo Zhou, Jianping Jin, Dali Li, Mingyao Liu, Yihua Chen
In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15. Signal transduction and targeted therapy 5 (1) (2020)
Di Ge, Lina Han, Feifei Yang, Na Zhao, Yang Yang, Jun-Sheng Zhang, Yihua Chen
Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities. MedChemComm 10 (10) (2019)
Feifei Yang, Na Zhao, Di Ge, Yihua Chen
Next-generation of selective histone deacetylase inhibitors. RSC advances 9 (34) (2019)
Yunqi Li, Yuan He, Ting Shao, Haixiang Pei, Weikai Guo, Dazhao Mi, Isabelle Krimm, Yuanjin Zhang, Pei-Li Wang, Xin Wang, Mingyao Liu, Zheng-Fang Yi, Yihua Chen
Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin. Journal of medicinal chemistry 62 (10) (2019)
Haixiang Pei, Yangrui Peng, Qiuhua Zhao, Yihua Chen
Small molecule PROTACs: an emerging technology for targeted therapy in drug discovery. RSC advances 9 (30) (2019)
T Shao, W Tang, Y Li, D Gao, K Lv, P He, Y Song, S Gao, M Liu, Yihua Chen, Zheng-Fang Yi
Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar. Journal of the European Academy of Dermatology and Venereology : JEADV 34 (3) (2019)

Yihua Chen.css-eqlu8i{font-size:small;padding-left:4px;} (Y Chen)

Publication Activity (10 Years)

Top Topics

Top Venues

Yihua Chen (Y Chen)