S1PR1 and VEGFR2 - a synergy that promotes tumor angiogenesis?

Vijay Avin Balaji RagunathraoVigneshwaran VellingiriMumtaz AnwarMd Zahid AkhterDolly Mehta

Published in: Molecular & cellular oncology (2020)

We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1-/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and growth, indicating combining S1PR1 antagonist with anti-VEGF/VEGFR2 therapy may eradicate resistant tumors.

Keyphrases

vascular endothelial growth factor
endothelial cells
high glucose
randomized controlled trial
systematic review
metabolic syndrome
stem cells
mesenchymal stem cells
oxidative stress