Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells.
Tomoki TakashinaAkihiro MatsunagaYukiko ShimizuTetsushi SakumaTadashi OkamuraKunie MatsuokaTakashi YamamotoYukihito IshizakaPublished in: Hepatology communications (2023)
Taken together with observations that 4F-Heps were not tumorigenic in immunocompromised mice for at least 2 years, we propose that this artificial transcription system is a versatile tool for cell therapy for hepatic failures.
Keyphrases
- mesenchymal stem cells
- endothelial cells
- cell therapy
- single cell
- umbilical cord
- induced pluripotent stem cells
- transcription factor
- pluripotent stem cells
- high fat diet induced
- liver injury
- type diabetes
- stem cells
- respiratory failure
- amino acid
- metabolic syndrome
- adipose tissue
- small molecule
- drug induced
- extracorporeal membrane oxygenation