Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.
Hyunjung BaekHyo Jung ShinJwa-Jin KimNara ShinSena KimMin-Hee YiEnji ZhangJinpyo HongJoon Won KangYonghyun KimCuk-Seong KimDong Woon KimPublished in: Journal of neuroinflammation (2017)
These data suggest that LPS-induced NF-κB signaling and inflammatory mediator expression are modulated by cilia and that the blockade of primary cilium formation by Kif3a siRNA regulates TLR4-induced NF-κB signaling. We propose that primary cilia are critical for regulating NF-κB signaling events in neuroinflammation and in the innate immune response.
Keyphrases
- lps induced
- inflammatory response
- immune response
- toll like receptor
- lipopolysaccharide induced
- signaling pathway
- nuclear factor
- poor prognosis
- dendritic cells
- pi k akt
- electronic health record
- binding protein
- spinal cord injury
- big data
- cancer therapy
- cell proliferation
- high glucose
- long non coding rna
- drug delivery
- blood brain barrier
- hyaluronic acid
- data analysis
- temporal lobe epilepsy