A reduction in the vascular smooth muscle cell focal adhesion component syndecan-4 is associated with abdominal aortic aneurysm formation.

Jiaxin HuYuyu LiZhonghai WeiHaiting ChenXuan SunQing ZhouQi ZhangYong YinMeng GuoJianzhou ChenGuangyao ZhaiBiao XuJun Xie

Published in: Clinical and translational medicine (2022)

We herein demonstrated that silencing SDC4 was associated with increased AAA formation and phenotypic changes in VSMCs via the RhoA-F/G-actin-MRTF-A pathway. These findings indicated that a reduction in SDC4 expression was an important pathological alteration and potential therapeutic target for AAA formation.

Keyphrases

smooth muscle
abdominal aortic aneurysm
poor prognosis
single cell
cell migration
risk assessment
pseudomonas aeruginosa
angiotensin ii
biofilm formation
human health
cell adhesion