Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice.

Yingxi WuHaijian WuJianxiong ZengBrock PluimerShirley DongXiaochun XieXinying GuoTenghuan GeXinyan LiangSudi FengYouzhen YanJian-Fu ChenNaomi Sta MariaQingyi MaFernando Gomez-PinillaZhen Zhao

Published in: Acta neuropathologica communications (2021)

Our data demonstrated that microvascular injury plays a key role in the pathogenesis of AD after mTBI. Therefore, restoring vascular functions might be beneficial for patients with mTBI, and potentially reduce the risk of developing AD.

Keyphrases

mild traumatic brain injury
electronic health record
cognitive decline
high fat diet induced
big data
metabolic syndrome
insulin resistance
deep learning