Mechanistic aspects of photobiomodulation therapy in the nervous system.
Fatemeh RamezaniAli Neshasteh-RizAlireza GhadaksazSeyedalireza Moghadas FazeliAtousa JanzadehMichael R HamblinPublished in: Lasers in medical science (2021)
Photobiomodulation therapy (PBMT) previously known as low-level laser therapy (LLLT) has been used for over 30 years, to treat neurological diseases. Low-powered lasers are commonly used for clinical applications, although recently LEDs have become popular. Due to the growing application of this type of laser in brain and neural-related diseases, this review focuses on the mechanisms of laser action. The most important points to consider include the photon absorption by intracellular structures; the effect on the oxidative state of cells; and the effect on the expression of proteins involved in oxidative stress, inflammation, pain, and neuronal growth.
Keyphrases
- oxidative stress
- induced apoptosis
- poor prognosis
- chronic pain
- cerebral ischemia
- high resolution
- high speed
- neuropathic pain
- ischemia reperfusion injury
- multiple sclerosis
- long non coding rna
- resting state
- spinal cord
- mass spectrometry
- white matter
- brain injury
- living cells
- spinal cord injury
- cell therapy
- reactive oxygen species
- subarachnoid hemorrhage
- smoking cessation
- fluorescent probe
- functional connectivity
- heat shock
- drug induced