Predominance of Central Memory T Cells with High T-Cell Receptor Repertoire Diversity is Associated with Response to PD-1/PD-L1 Inhibition in Merkel Cell Carcinoma.
Ivelina SpassovaSelma UgurelPatrick TerheydenAntje SuckerJessica C HasselCathrin RitterLinda KubatDaniel HabermannFarnoush FarahpourMohammadkarim SaeedghalatiLukas PeifferRajiv KumarDavid SchramaDaniel HoffmannDirk SchadendorfJürgen Christian BeckerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our explorative study identified new tumor tissue-based molecular characteristics associated with response to anti-PD-1/PD-L1 therapy in MCC. These observations warrant further investigations in larger patient cohorts to confirm their potential value as predictive markers.