Guideline directed medical therapy and reduction of secondary mitral regurgitation.

Georg SpinkaPhilipp E BartkoGregor HeitzingerSuriya PrausmüllerMax-Paul WinterHenrike ArfstenGuido StrunkRaphael RosenhekStefan KastlChristian Hengstenberg Noemi PavoMartin HülsmannGeorg Goliasch

Published in: European heart journal. Cardiovascular Imaging (2022)

The present study provides comprehensive evidence for the effectiveness of contemporary GDMT to specifically improve SMR. Our data indicate that GDMT titration conveys a three-fold increased chance of reducing SMR severity. Moreover, the dosage effects of ARNi, as well as the combination of RASi and MRA, BB and MRA, and all three substances in the aggregate are able to significantly improve SMR.

Keyphrases

contrast enhanced
randomized controlled trial
healthcare
electronic health record
growth factor
drinking water
computed tomography
big data
magnetic resonance imaging
mesenchymal stem cells
smoking cessation
replacement therapy