Login / Signup

D614G Spike Variant Does Not Alter IgG, IgM, or IgA Spike Seroassay Performance.

Carleen Klump-ThomasHeather KalishJennifer HicksJennifer MehalkoMatthew DrewMatthew J MemoliMatthew D HallDominic EspositoKaitlyn Sadtler
Published in: medRxiv : the preprint server for health sciences (2020)
Emergence of a new variant of spike protein (D614G) with increased infectivity and transmissibility has prompted many to analyze the potential role of this variant in the SARS-CoV-2 pandemic. When a new variant emerges, there is a concern regarding whether an individual exposed to one variant of a virus will have cross-reactive immune memory to the second variant. Accordingly, we analyzed the serologic reactivity of D614 (original) and G614 variant spike proteins. We found that antibodies from a high-incidence population in New York City reacted both toward the original D614 spike and the G614 spike variant. These data suggest that patients who have been exposed to either SARS-CoV-2 variant have humoral immunity that can respond against both variants. This is an important finding both for SARS-CoV-2 disease biology and for potential antibody-based therapeutics.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • gene expression
  • immune response
  • newly diagnosed
  • risk factors
  • coronavirus disease
  • risk assessment
  • small molecule
  • dna methylation
  • protein protein