Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease.

Xuejing SunYao Lu Junru Wu Qing WenZhengxin LiYan TangYunmin ShiTian HeLun LiuWei HuangChunyan WengQing Wu Qingzhong XiaoHong YuanQingbo Xu Jingjing Cai

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.

Keyphrases

single cell
rna seq
systematic review
high throughput
randomized controlled trial
meta analyses
big data
data analysis