Glial cell line-derived neurotrophic factor contributes to alcoholic-induced liver injury by regulating the NF-κB pathway.

Xuling LiuGuangyue YangTiantian SunLe TaoDongxiao ShenWei ZhangJie ZhangDongying XueBei ChenLiu WuCheng LiuWenting Ma

Published in: Alcoholism, clinical and experimental research (2022)

The concentration of GDNF is increased in the circulation of ALD patients. GDNF promotes alcohol-induced liver injury and inflammation via the activation of NF-κB, which mediates hepatocyte injury and inflammatory cytokine expression. Based on these findings, GDNF is a potential therapeutic target for preventing or ameliorating liver injury in ALD.

Keyphrases

liver injury
drug induced
oxidative stress
signaling pathway
end stage renal disease
lps induced
ejection fraction
newly diagnosed
poor prognosis
peritoneal dialysis
nuclear factor
prognostic factors
spinal cord injury
cell proliferation
patient reported outcomes
long non coding rna
inflammatory response