Novel agonist- and antagonist-based radioligands for the GLP-2 receptor - useful tools for studies of basic GLP-2R pharmacology.
Sarina GadgaardWijnand J C van der VeldenSine P SchiellerupJenna Elizabeth HuntMaria B N GabeJohanne Agerlin WindeløvGeke Aline BoerHannelouise KissowCathrine ØrskovJens J HolstBolette HartmannMette Marie RosenkildePublished in: British journal of pharmacology (2021)
We successfully developed two new radioligands and identified SEMF as a major site for GLP-2R expression. Moreover, we showed different binding kinetics of full agonist versus weak partial agonist with antagonistic properties.