Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes.

Christian B LindstadShuo-Wang QiaoMarie K JohannesenLars FuggerLudvig M SollidM Fleur du Pré

Published in: European journal of immunology (2020)

We created a TCR transgenic mouse with CD4+ T cells recognizing the immunodominant DQ2.5-glia-ω2 gluten epitope. We show that these cells respond to deamidated gluten feed in vivo and compare them to previously published α2- and γ1-specific mice. These mice may help enlighten key aspects of celiac disease pathogenesis.

Keyphrases

celiac disease
high fat diet induced
induced apoptosis
cell cycle arrest
randomized controlled trial
oxidative stress
endoplasmic reticulum stress
immune response
metabolic syndrome