Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS.
Nicola LatronicoElena PeliStefano CalzaFederica RodellaMaria Paola NovelliAndrea CellaJohn MarshallDale M NeedhamFrank Antony RasuloSimone Pivanull nullPublished in: Thorax (2021)
We report on the outcome of 114 COVID-19-associated acute respiratory distress syndrome (ARDS) survivors evaluated at 3, 6 and 12 months after intensive care unit discharge with assessment of physical, mental and cognitive impairments. Critical illness polyneuromyopathy was diagnosed in 23 patients (39%). Handgrip dynamometry was 70% predicted at 3 months and significantly improved over time, whereas the 6 min walk test (80% predicted) and severe fatigue (27% of patients) did not. Independence in activities of daily living (ADL) was achieved by 98% at 3 months. Cognitive impairment (28% at 3 months) improved over time, whereas depression, anxiety and post-traumatic stress disorder symptoms, present in 9%, 10% and 4% at 3 months, did not. Normalised health-related quality of life was good. COVID-19-associated ARDS leads to persisting impairment in performance-based measures of physical function, while ADL, cognitive and mental health status, and health-related quality of life may be less impaired. Trial registration number NCT04608994.
Keyphrases
- acute respiratory distress syndrome
- mental health
- mechanical ventilation
- coronavirus disease
- extracorporeal membrane oxygenation
- intensive care unit
- end stage renal disease
- sars cov
- newly diagnosed
- ejection fraction
- cognitive impairment
- peritoneal dialysis
- sleep quality
- physical activity
- depressive symptoms
- prognostic factors
- type diabetes
- randomized controlled trial
- clinical trial
- patient reported outcomes
- study protocol
- mental illness
- early onset
- skeletal muscle
- double blind
- glycemic control