Survival and maturation of human induced pluripotent stem cell-derived dopaminergic progenitors in the Parkinsonian rat brain is enhanced by transplantation in a neurotrophin-enriched hydrogel.
Giulia CominiRachel KellySarah JarrinTommy PattonKaushik NarasimhanAbhay PanditNicola DrummondTilo KunathEilis DowdPublished in: Journal of neural engineering (2024)
The data strongly supports further investigation of supportive hydrogels for improving the outcome of iPSC-derived brain repair in Parkinson's disease.
Keyphrases
- induced pluripotent stem cells
- endothelial cells
- drug delivery
- high glucose
- hyaluronic acid
- tissue engineering
- wound healing
- diabetic rats
- electronic health record
- resting state
- white matter
- pluripotent stem cells
- cell therapy
- drug release
- drug induced
- functional connectivity
- stem cells
- cerebral ischemia
- free survival
- machine learning
- subarachnoid hemorrhage
- deep learning
- bone marrow