Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities.
Chong ShangYun-Bao MaYuan WangXiao-Feng HeTian-Ze LiJi-Jun ChenPublished in: Archives of pharmacal research (2023)
Artemongolins A-K (1-11), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1, 4, and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A-K (1-11) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluation against three human hepatoma cell lines demonstrated that the most active compounds 5 and 6 displayed inhibitory activity with IC 50 values of 88.6 and 57.0 (HepG2), 59.1 and 26.4 (Huh7), and 67.5 and 32.5 (SK-Hep-1) µM, respectively.
Keyphrases
- high resolution
- endothelial cells
- dual energy
- solid state
- magnetic resonance
- electronic health record
- density functional theory
- optical coherence tomography
- molecular dynamics
- induced pluripotent stem cells
- molecular dynamics simulations
- pluripotent stem cells
- big data
- mass spectrometry
- data analysis
- deep learning