Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of atrial fibrillation.

Emile C A NynsVincent PorteroShanliang DengTianyi JinNiels HarlaarCindy I BartThomas J van BrakelMeindert PalmenJesper HjortnaesArti A RamkisoensingGuo Qi ZhangRené H PoelmaBalázs ÖrdögAntoine A F de VriesDaniel A Pijnappels

Published in: Journal of internal medicine (2023)

Transthoracic optogenetic cardioversion of AF is effective in the aged rat heart using irradiation levels compatible with human atrial transmural light penetration.

Keyphrases

atrial fibrillation
catheter ablation
left atrial
oral anticoagulants
endothelial cells
left atrial appendage
heart failure
direct oral anticoagulants
percutaneous coronary intervention
pluripotent stem cells
left ventricular
mitral valve
acute coronary syndrome