Proteome-wide discovery of cortical proteins that may provide motor resilience to offset the negative effects of pathologies in older adults.

Aron S BuchmanLei YuHans-Ulrich KleinAndrea R ZammitShahram OveisgharanFrancine GrodsteinShinya TasakiAllan I LeveyNicholas T SeyfriedDavid A Bennett

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)

Cortical proteins may provide more or less motor resilience in older adults. These proteins are high value therapeutic targets for drug discovery that may lead to interventions that maintain motor function despite the accumulation of as yet untreatable brain pathologies.

Keyphrases

drug discovery
physical activity
social support
small molecule
resting state
depressive symptoms
multiple sclerosis
blood brain barrier
subarachnoid hemorrhage
cerebral ischemia