Identification of extracellular matrix proteins in plasma as a potential biomarker for intervertebral disc degeneration.

Sharon Miracle Nayagam Karthik Ramachandran Ganesh Selvaraj R Sunmathi Murugesh Eswaran Narmatha Devi Palraj Karuppanan Sukumaran Sri Vijay Anand Raveendran Muthurajan Chitraa Tangavel Dr Shanmuganathan Rajasekaran

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2024)

The distinct presence of collagen type 2a1 and the elevated expression of aggrecan in IVDD plasma may serve as the basis for the development of a potential biomarker for monitoring the progression of disc degeneration.

Keyphrases

extracellular matrix
poor prognosis
binding protein
long non coding rna