Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo.

Minchao LvQingxin XuBei ZhangZhiqiang YangJun XieJinku GuoFeixiong HeWei Wang

Published in: Cancer cell international (2021)

This work firstly revealed that imperatorin induced autophagy and cell cycle arrest through PTEN-PI3K-AKT-mTOR/p21 signaling pathway by targeting and up-regulating PTEN in human osteosarcoma cells. Hence, imperatorin is a desirable candidate for clinical treatments of osteosarcoma.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
induced apoptosis
cell death
endothelial cells
cell proliferation
epithelial mesenchymal transition
endoplasmic reticulum stress
high glucose
induced pluripotent stem cells
oxidative stress
cell cycle
pluripotent stem cells
diabetic rats
drug induced