PVT1 promotes proliferation and macrophage immunosuppressive polarization through STAT1 and CX3CL1 regulation in glioblastoma multiforme.

Lijie HuangZheng WangChihyi LiaoZheng ZhaoHua GaoRuoyu HuangJing ChenFan WuFan ZengYing ZhangTao Jiang Huimin Hu

Published in: CNS neuroscience & therapeutics (2024)

PVT1 plays a significant role in GBM, correlating with poor prognosis, promoting cell growth, and shaping an immunosuppressive TME via STAT1 and CX3CL1 regulation. Targeting PVT1 may hold therapeutic promise for GBM patients.

Keyphrases

poor prognosis
end stage renal disease
long non coding rna
newly diagnosed
ejection fraction
chronic kidney disease
signaling pathway
adipose tissue
prognostic factors
peritoneal dialysis
big data
cancer therapy
patient reported outcomes
machine learning
artificial intelligence
deep learning