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Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes.

Amand Floriaan SchmidtRoshni JoshiMaria Gordillo-MarañónFotios DrenosPimphen CharoenClaudia GiambartolomeiJoshua C BisTom R GauntAlun D HughesDeborah A LawlorAndrew WongJackie F PriceNishi ChaturvediGoya WannametheeNora FranceschiniMika KivimakiAroon D HingoraniChristopher Finan
Published in: Communications medicine (2023)
The cholesterol content of a wide range of lipoprotein and apolipoproteins associate with measures of atherosclerosis, blood pressure, CRP, and CHD, with a subset affecting HF, T2DM, AD and IBD risk. Many of the observed effects appear to act independently of LDL-C, HDL-C, and TG, supporting the targeting of lipid fractions beyond LDL-C for disease prevention.
Keyphrases
  • low density lipoprotein
  • blood pressure
  • cardiovascular disease
  • heart rate
  • hypertensive patients
  • cancer therapy
  • fatty acid
  • adipose tissue
  • metabolic syndrome
  • drug delivery
  • ulcerative colitis