Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D.

Mohamed Abu-FarhaIrina Al-KhairiPreethi CherianBetty ChandyDevarajan SriramanAsma AlhubailFaisal Al-RefaeiAbdulmohsen AlTerkiJehad Abubaker

Published in: Lipids in health and disease (2016)

In conclusion, our data shows that ANGPTL3, 4 and 8 are increased in obesity and T2D. ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 in the obese and T2D subjects. Taken together, this data highlight the role of these proteins in metabolic diseases and how they interact with each other's under different physiological and pathophysiological conditions.

Keyphrases

type diabetes
weight loss
metabolic syndrome
insulin resistance
adipose tissue
big data
poor prognosis
weight gain
bariatric surgery
body mass index
machine learning
skeletal muscle
long non coding rna
physical activity
artificial intelligence