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External validity of randomized clinical trial studying preventing depressive symptoms following acute coronary syndrome.

Michael Tvilling MadsenKnud JuelErik SimonsenIsmail GögenurAnn Dorthe Olsen Zwisler
Published in: Brain and behavior (2021)
Significant differences were present between noneligible patients and participants; however, more troublingly significant differences were shown between nonconsenting patients and participants. The presence of depressive symptoms and anxiety has a significant impact on patients' willingness to give informed consent in clinical trials in cardiology with a focus on psychological outcomes.
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