External validity of randomized clinical trial studying preventing depressive symptoms following acute coronary syndrome.
Michael Tvilling MadsenKnud JuelErik SimonsenIsmail GögenurAnn Dorthe Olsen ZwislerPublished in: Brain and behavior (2021)
Significant differences were present between noneligible patients and participants; however, more troublingly significant differences were shown between nonconsenting patients and participants. The presence of depressive symptoms and anxiety has a significant impact on patients' willingness to give informed consent in clinical trials in cardiology with a focus on psychological outcomes.
Keyphrases
- end stage renal disease
- depressive symptoms
- acute coronary syndrome
- ejection fraction
- newly diagnosed
- clinical trial
- chronic kidney disease
- randomized controlled trial
- peritoneal dialysis
- type diabetes
- metabolic syndrome
- open label
- cardiac surgery
- acute kidney injury
- physical activity
- atrial fibrillation
- study protocol