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The use of therapeutic plasma exchange as adjunctive therapy in the treatment of coronavirus disease 2019: A critical appraisal of the current evidence.

Wen LuWalter KelleyDeanna C FangSarita JoshiYoung KimMonika ParoderYvette C TanhehcoMinh-Ha TranHuy P Pham
Published in: Journal of clinical apheresis (2021)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a major pandemic. While vaccine development moves forward, optimal treatment continues to be explored. Efforts include an ever-expanding number of clinical trials along with newly proposed experimental and off-label investigational therapies; one of which is therapeutic plasma exchange (TPE). There have been a number of publications on TPE use as adjunctive therapy for coronavirus disease 2019 (COVID-19), but no prospective randomized controlled trials (RCTs) have been completed. This article critically appraises the current available evidence on TPE as a treatment modality for SARS-CoV-2 infection.
Keyphrases
  • coronavirus disease
  • respiratory syndrome coronavirus
  • sars cov
  • clinical trial
  • randomized controlled trial
  • systematic review
  • stem cells
  • bone marrow
  • quality improvement
  • replacement therapy