A double-blind, randomized, placebo-controlled pilot trial of atorvastatin for nephrogenic diabetes insipidus in lithium users.
Jocelyn Fotso SohSerge BeaulieuFrancesco TrepiccioneOuti LinnarantaGabriela Torres-PlatasRobert W PlattSuzane RenaudChien-Lin SuIstvan MucsiLuciano D'ApolitoBenoit H MulsantAndrea LevinsonSybille SauryDaniel MüllerAyal SchafferAnnemieke DolsNancy LowPablo CervantesBirgitte M ChristensenNathan HerrmannTarek K RajjiSoham RejPublished in: Bipolar disorders (2020)
Among lithium users with NDI, atorvastatin 20 mg/d did not significantly improve urinary osmolality compared to placebo over a 12-week period. Larger confirmatory trials with longer follow-up periods may help to further assess the effects of statins on NDI, especially within patients with more severe NDI.