Low expression of NSD1, NSD2, and NSD3 define a subset of human papillomavirus-positive oral squamous carcinomas with unfavorable prognosis.
Steven F GameiroFarhad GhasemiPeter Y F ZengNeil MundiChristopher J HowlettPaul PlantingaJohn W BarrettAnthony C NicholsJoe S MymrykPublished in: Infectious agents and cancer (2021)
These results starkly illustrate the contrast in molecular features between HPV+ and HPV- HNSCC tumors and suggest that NSD1, NSD2, and NSD3 expression levels should be further investigated as novel clinical metrics for improved prognostication and patient stratification in HPV+ HNSCC.