The impact of vitamin D on type 2 diabetes management: boosting PTP1B gene expression and physical activity benefits in rats.

Kimya Khaledi Rastegar Hoseini Ehsan Amiri

Published in: Genes & nutrition (2024)

The present study shows that the combined AT and Vit D supplementation positively impacts the expression of PTP1B in adipose tissue and serum irisin in rats with T2D. These findings suggest that combining AT with Vit D supplementation can provide a new and effective strategy to improve glucose tolerance and diabetes-related factors in individuals with T2D by regulating the expression of PTP1B in adipose tissue and promoting the synthesis of beneficial irisin protein.

Keyphrases

adipose tissue
type diabetes
gene expression
poor prognosis
insulin resistance
physical activity
glycemic control
binding protein
cardiovascular disease
high fat diet
dna methylation
body mass index
long non coding rna
metabolic syndrome
depressive symptoms
skeletal muscle