ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms.
Alberto J ArribasSara NapoliLuciano CascioneLaura BarnabeiGiulio SartoriEleonora CannasEugenio GaudioChiara TarantelliAfua Adjeiwaa MensahFilippo SprianoAntonella ZucchettoFrancesca Maria RossiAndrea RinaldiManuel Castro de MouraSandra JovicRoberta Bordone PittauAnastasios StathisGeorg StussiValter GatteiJennifer R BrownManel EstellerEmanuele ZuccaDavide RossiFrancesco BertoniPublished in: bioRxiv : the preprint server for biology (2023)
A mechanism of secondary resistance to the PI3Kδ and BTK inhibitors in B cell neoplasms driven by secreted factors.Resistance can be reverted by targeting ERBB signaling.
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